There appeared to be a small, though dose-dependent, increase in early resorptions and post-implantation loss; however, the increase did not reach statistical significance and the high dose values were relatively similar to those reported in the historical control data ( Table 7 ).
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Toxicological evaluation of two novel bitter modifying flavour compounds: 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1<i>H</i>-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione and 3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1<i>H</i>-pyrazol-4-yl)-1-(3-hydroxybenzyl)-5,5-dimethylimidazolidine-2,4-dione.
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