Downregulation of nicotinic and muscarinic receptor function in rats after subchronic exposure to diazinon.

According to this study, the difference between calculated LD 50 values was over 100 mg/kg bw, but the potency value of 0.84 did not reach statistical significance (safety margins from 0.68 to 1.04). 3.2 Contraction of isolated rat diaphragm We used the antagonists of nAChR—mecamylamine (100 and 300 μM) and pancuronium (2 μM), in order to prove that EFS technique induced muscle contractions only across neuromuscular end-plate.

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