Human monocyte-derived dendritic cells exposed to hyperthermia show a distinct gene expression profile and selective upregulation of <i>IGFBP6</i>.

Surprisingly, we found that although overall upregulation of the three genes was observed (Figure 2A ), IGFBP6 was the only gene in which statistical significance could be demonstrated ( p = 0.004), whereas PLAT ( p = 0.089) and MANF ( p = 0.05) did not reach statistical significance, probably due to variability in expression levels in a small cohort.

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