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Characterization of Reconstructed Ancestral Proteins Suggests a Change in Temperature of the Ancient Biosphere.

Life (Basel) · 2017 · PMC5617958 · PMID 28783077

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showed a trendno p-value reported
From these experiments, they observed that the mutant proteins showed a trend toward greater thermal stability than the wild-type proteins.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.