Selective HDL-Raising Human Apo A-I Gene Therapy Counteracts Cardiac Hypertrophy, Reduces Myocardial Fibrosis, and Improves Cardiac Function in Mice with Chronic Pressure Overload.

A comparison of Kaplan–Meier survival curves showed a clear trend ( p = 0.0678) for a lower mortality rate in AAV8-A-I TAC mice compared to control TAC mice (hazard ratio for mortality of 0.543; 95% confidence interval (CI): 0.282 to 1.05) during eight weeks of follow-up ( Figure 1 ).

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