Third, in the subgroup analysis according to the type of cancer, for ESCC patients, loss of KLF4 expression showed a trend of better prognosis though without statistical significance (HR = 0.83, 95% CI: 0.57–1.23, P = 0.355) which suggested that, similar to head and neck squamous cell carcinoma (HNSCC) [ 45 ], KLF4 might be a malignant transformation-related gene in ESCC, which still needs further investigation.
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The Prognostic Value of Decreased KLF4 in Digestive System Cancers: A Meta-Analysis from 17 Studies.
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