Effects of Incretin-Based Therapies on Diabetic Microvascular Complications.

In the LEADER study, the incidence rate of DR, defined as the need for retinal photocoagulation or treatment with intravitreal agents, vitreous hemorrhage, or the onset of diabetes-related blindness, was slightly higher in the liraglutide group (i.e., 0.6 events/100 patient-years) than in the placebo group (i.e., 0.5/100 patient-years), and the HR for DR was 1.15 (95% CI, 0.87 to 1.52), although it did not reach statistical significance ( P =0.33) [ 11 ].

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