Somatic Arc protein expression in hippocampal granule cells is increased in response to environmental change but independent of task-specific learning.

There was a strong trend toward a reduced number of Arc + cells in the dentate granule cell layer of aged mice, compared with young adult mice (unpaired t-test with Welch’s correction t = 2.16, df = 10.4, P = 0.055, for adult: 21.9 ± 1.6 (n = 6) vs. aged: 17.4 ± 1.4 (n = 7); Fig. 5C ).

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