Pharmacological and non-pharmacological treatments for major depressive disorder: review of systematic reviews.

44 Likewise, patients who used physical exercise discontinued treatment because of adverse events less often than those treated with antidepressants (0% vs 6%; RR 0.15; 95% CI 0.01 to 2.86), but the difference did not reach statistical significance. 44 Little evidence on treatment discontinuation was available for most CAM interventions, particularly for Chinese herbal medicine or saffron. 30 31 Discussion Out of more than 140 interventions of interest, our review identified only five treatments for which the general efficacy for acute-phase MDD is supported by reliable evidence (ie, evidence graded as high or moderate strength of evidence).

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