Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.

At positions 172, 961, and 1068 (the native residues are leucine, methionine, and phenylalanine, respectively) substitutions caused both increases and decreases in open probability ( Figure 4D,I,N ), and the underlying changes in gating pattern were similar ( Figure 4A,F,K ): a clear trend for an association of lengthened bursts with shortened interbursts and of shortened bursts with lengthened interbursts could be observed (compare Figs.

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