Switches in Genomic GC Content Drive Shifts of Optimal Codons under Sustained Selection on Synonymous Sites.

Genome Biol Evol · 2017 · PMC5629928 · PMID 27540085

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a strong trendno p-value reported

Consistent with the latter explanation is that recent mutations showed a strong trend towards AT with 84% of GC-changing SNPs in G. vaginalis , whereas the mutations towards GC in L. fermentum and L. delbrueckii were 65% and close to 50% of AT-changing single nucleotide substitutions, respectively.

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