Initial elevations in glutamate and dopamine neurotransmission decline with age, as does exploratory behavior, in LRRK2 G2019S knock-in mice.

(2016) also found a similar increase in SPN event frequency in slices from similar GKI mice (aged < 1 month) ( Matikainen-Ankney et al., 2016 ), which was concluded to be predominantly due to action potential-mediated transmission (only a strong trend toward increased frequency was observed in the presence TTX).

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We found that GKI event amplitudes and frequencies were insensitive to TTX application ( Figure 2—figure supplement 3 ), with only a weak trend toward increased (not reduced) frequency following blockade of action potential firing.

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