14 , 15 , 16 Intrarater reliability for WMH was highly significant. 15 Briefly, nonbrain elements were manually removed from the image by operator‐guided tracing of the dura mater within the cranial vault, including the middle cranial fossa but excluding posterior fossa structures.
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Subclinical Cerebrovascular Disease Increases the Risk of Incident Stroke and Mortality: The Northern Manhattan Study.
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Those with SBI showed a nonsignificant trend toward greater risk of vascular mortality (HR: 1.6; 95% CI, 1.0–2.6) but not nonvascular, mortality (HR: 1.0; 95% CI, 0.6–1.5).
When divided into quartiles of WMHV, those in the upper 3 had greater risk of all mortality, and this reached significance for the top quartile (HR: 2.0; 95% CI, 1.3–3.1), which was also associated with vascular mortality (HR: 2.0; 95% CI, 1.3–3.1), with a trend for an association with nonvascular mortality that did not reach statistical significance (Table 2 ).