Cardiovascular Benefits of Moderate Exercise Training in Marfan Syndrome: Insights From an Animal Model.

While the presence of PSS remained unaltered (71%) at the 9‐month time‐point in MF‐Sed mice, it showed a decreasing trend in MF‐Ex mice (PSS 40%, P =0.12, McNemar test) (Figure 5 ).

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A similar trend was previously reported in the same mouse strain, but failed to reach significance, likely because of the limited sample size and large intrinsic variability. 30 The clinical and physiological significance of such fibrosis is unknown, but could contribute to some characteristics of MF cardiomyopathy.

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WT‐Ex mice showed a slight increase in pulsatility compared with WT‐Sed, but it did not reach statistical significance.

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