Supplementation of omega 3 fatty acids may improve hyperactivity, lethargy, and stereotypy in children with autism spectrum disorders: a meta-analysis of randomized controlled trials.

Meta-analysis investigating changes in ASD severity in patients treated with omega 3 or placebo Primary outcome: changes of ABC Among the four eligible articles (n=109) comparing changes of ABC scale severity between ASD children treated with omega 3 and those treated with placebo, there were only borderline significance of better treatment effects of the omega 3 treatment group in ABC scores of hyperactivities ( k =4, Hedges’ g =−0.348, 95% CI =−0.716 to 0.021, P -value =0.064; difference in means =−2.692, 95% CI =−5.364 to −0.020, P =0.048) ( Figure 2A ) without significant heterogeneity ( Q value =1.553, df =3, P -value =0.670, I 2 <0.001%, τ <0.001) or publication bias via inspection of funnel plot ( Figure S2A ) or Egger’s regression ( t value =0.943, df =2, two-tailed P -value =0.445).

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47 , 53 – 56 Moreover, the effects’ size for improvement in ABC hyperactivity subscale was small and only reached borderline significance (Hedges’ g =−0.348, 95% CI =−0.716 to 0.021).

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