A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.

Hum Mol Genet · 2017 · PMC5639461 · PMID 29016847

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Both genotypes showed a similar distribution of the levels of activity within individual bouts, but the Gria3 A653T mice showed a trend for a decrease in the number of ‘low-intensity’ activity bouts ( Fig. 7A , upper panel).

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