Nasal DNA methylation differentiates corticosteroid treatment response in pediatric asthma: A pilot study.

Given the significant associations between DNAm and treatment response and the good alignment between DNAm and genotypes, it is not surprising that in the 20 subjects who had 450K array data, all the sites showed statistically significant or marginally significant genetic associations with responder status.

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In OTX2 , moderate negative correlation was detected between expression and DNAm but did not reach statistical significance (Spearman r = -0.3 for all sites, p value ranging from 0.08–0.12, S1A Fig ).

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When all 33 genotyped subjects were analyzed using additive models, similar genetic associations were observed ( Table 3 ); significant associations remained for four sites (rs12282251, rs66630638, rs73006518 and rs76828276) while the other two (rs34756202 and rs73006518) showed marginal significance.

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