Targeted N-glycan deletion at the receptor-binding site retains HIV Env NFL trimer integrity and accelerates the elicited antibody response.

PLoS Pathog · 2017 · PMC5640423 · PMID 28902916

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a strong trendno p-value reported

There was also a strong trend of more potent neutralization of the 16055Δ463 virus in this group after three immunizations, while the neutralization titer pattern for other single N-glycan-deleted viruses (16055Δ301 and 16055Δ360) was similar to the wt virus neutralization pattern at this time point.

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