Genetic induction of hypometabolism by ablation of MC4R does not suppress ALS-like phenotypes in the G93A mutant SOD1 mouse model.

Female and male MC4R −/− mice, in comparison, consumed more food than WT mice (4–5 g and 6–7 g respectively) at these time points but this did not achieve significance in post hoc analyses.

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Male G93A;MC4R −/− mice consumed more food than G93A mice at all age points, but this did not reach statistical significance.

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