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Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site during Circulation in Humans.

J Virol · 2017 · PMC5640874 · PMID 28814525

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showed a trendno p-value reported
When a more stringent mixture ratio of 5:1 (wild type/mutant) was used, the PR8/NS1-L95I virus also showed a trend to outcompete the wild-type virus, although, as expected, this took more passages ( Fig. 8B ).

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