Improved Progression-Free Survival in Irinotecan-Treated Metastatic Colorectal Cancer Patients Carrying the HNF1A Coding Variant p.I27L.

Front Pharmacol · 2017 · PMC5641335 · PMID 29066969

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nearly significantno p-value reported

The strong negative correlation between hepatic expression of ABCC1 and HNF1A and the nearly significant positive correlation between ABCC2 and HNF1A observed in the GTEx cohort sustain a functional interaction, yet an inverse regulatory influence of HNF1A on these two transporters.

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