Synaptic activity protects against AD and FTD-like pathology via autophagic-lysosomal degradation.

Western blot analyses showed that levels of immature cathepsin D are increased of 83±22% (with a trend for mature cathepsin D, which did not reach statistical significance) in Tg-NS compared to WT mice, and that DBS in Tg-S mice restored cathepsin D levels back to WT ( Figure 4f ; quantification in g and h).

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