Adipocyte glucocorticoid receptor is important in lipolysis and insulin resistance due to exogenous steroids, but not insulin resistance caused by high fat feeding.

In our work, we saw a reduction in Lipe and Lpin1 levels in AGRKO mice after high fat feeding that did not quite reach significance ( Supplementary Figure 2B ).

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Liver of AGRKO mice showed a trend toward a decrease of genes involved in lipid metabolism and gluconeogenesis with significant decrease of Mttp (microsomal triglyceride transfer protein ( Figure 1 D)), suggesting that TG and lipid homeostasis is slightly changed in AGRKO mice on HFD.

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