PD-1 Controls Tonic Signaling and Lymphopenia-Induced Proliferation of T Lymphocytes.

When we examined the expression of the anti-apoptotic molecule Bcl2 at 5 days post-cell transfer (a time during which rapid LIP was occurring), the PD-1 −/− cells in female Rag −/− hosts showed a trend toward expressing less of this molecule (Figure 2 C).

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