A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects.

The increase in newly generated CSF apoE approached but did not reach statistical significance between the two treatment groups ( P = .0538; Fig. 2 I) as indicated by the mean area under the concentration curve of newly generated apoE during the labeling period for the individual subjects ( Fig. 2 G) or group averaged values ( Fig. 2 H; ±95% CIs).

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