Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder.

Focusing on the subset of 66 genes with nominally significant PolyStrat scores, NRXN1 had the largest difference between cases and ExAC ( χ 2 = 82.3, df = 16, uncorrected p = 6.37 × 10 −11 ; corrected p = 1.27 × 10 −6 ) and no difference between controls and ExAC ( χ 2 = 10.5, df = 16, uncorrected p = 0.84) (Fig. 4d ).

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