Barely Significant
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Hypermethylation in the promoter of the <i>MTHFR</i> gene is associated with diabetic complications and biochemical indicators.

Diabetol Metab Syndr · 2017 · PMC5648437 · PMID 29075332

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showed a trendno p-value reported
Contrary to the methylation profile found in both the present work and in the Egyptian population, a recent study on a Chinese population showed a trend to hypomethylation of the MTHFR promoter in diabetic individuals with DN compared to healthy individuals [ 19 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.