Cardiovascular adaptation to hypoxia and the role of peripheral resistance.

Continuous monitoring of unrestrained, non-anesthetised mice via radio-telemetric catheterization showed that although resting heart rates were unchanged in all mutants relative to wild type controls (n = 7) through diurnal variation ( Figure 1A ), there was a constitutive hypotensive state in K14cre-HIF-2α mice (n = 7) and NOS2 mutants (n = 6) ( Figure 1B ) and a strong trend towards a hypertensive state in K14cre-HIF-1α mice.

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I don't see how differences in the heart rate changes as shown in Figure 8D or 8N should be highly significant.

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