Protein expression of TTF1 and cMYC define distinct molecular subgroups of small cell lung cancer with unique vulnerabilities to aurora kinase inhibition, DLL3 targeting, and other targeted therapies.

In contrast but as predicted, in the two parental cell lines that were sensitive to the Bcl2 inhibitor ABT-737 (H1417 and H889), cMYC overexpression lead to decrease in sensitivity (although this did not reach statistical significance ( p = 0.183) as the DMS79 parental cell line was not sensitive).

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