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Intrinsic BET inhibitor resistance in SPOP-mutated prostate cancer is mediated by BET protein stabilization and AKT-mTORC1 activation.

Nat Med · 2017 · PMC5653288 · PMID 28805822

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BRD2/3/4 mRNA expression was relative lower in SPOP-mutated tumors than that in SPOP-WT specimens in our cohorts, although the difference did not reach statistical significance (except BRD2 ) ( Supplementary Fig. 2c ).

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