Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism.

Sci Rep · 2017 · PMC5653857 · PMID 29062026

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In skeletal muscle, the expression of genes encoding BCKDHA and BCKDHB only showed a trend to decrease in the db/db group (Fig. 6c–e ), and the total levels of BCKDHA was reduced in db/db mice (Fig. 6f ) (50% reduced compared to the control group).

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