TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia.

Patients with TP53‐mutant tumours (median age 67.5 months, range 15–288) tended to be older at diagnosis compared to those with wildtype TP53 (median age 56.8 months, range 11–173), but this did not reach statistical significance (Figure 2 ).

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