Combined targeting of Raf and Mek synergistically inhibits tumorigenesis in triple negative breast cancer model systems.

Erk phosphorylation in vivo was essentially abolished with either AZD6244 alone, or the AZD6244-SFN combination (Figure 6B, 6D ); whereas SFN alone reduced Erk phosphorylation in only 2 of 6 tumors (Figure 6B ), and no significant difference was apparent across the whole cohort (Figure 6D ).

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