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CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction.

Pharmacogenomics J · 2018 · PMC5656562 · PMID 28440343

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Although we saw numerically higher dose-adjusted concentrations in CYP3A5 PM, particularly in Caucasians, our results did not reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.