95 A retrospective analysis of 45 RCC patients showed a trend toward increased PFS for patients with a C min ≥14.1 ng/mL of 13.3 vs. 3.9 months, P = 0.06. 96 Based on experience in transplant and pediatric patients, everolimus TDM seems feasible. 94 , 97 Although exposure–response relations are seen for everolimus in oncology, no formal PK‐target has been established yet.
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Practical Recommendations for Therapeutic Drug Monitoring of Kinase Inhibitors in Oncology.
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