Hsp90-downregulation influences the heat-shock response, innate immune response and onset of oocyte development in nematodes.

While the upregulation of Daf-21 up_2 is slightly weaker in the first experiment (UpRegScore of 70, 97 and 97, respectively), it is still clearly significant when compared to 100 random gene sets (UpRegScore: 3.7 ± 6.2, p<0.001) ( Fig 3A ).

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elegans and like in yeast information-rich networks are obtained with all tested parameters proving a highly significant network and cluster formation.

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