miR-16 and miR-103 impact 5-HT₄ receptor signalling and correlate with symptom profile in irritable bowel syndrome.

In contrast, an increased HTR4b_2 expression by both miR-16 A > G, mimicking the SNP situation, and miR-103, was observed although differences did not reach statistical significance (Supplementary Figure S3C ). miR-16 and miR-103 are significantly downregulated in the small intestine of IBS-D patients To further understand the role of the GI subregionally most abundant miR-16 and miR-103 in IBS, we performed comparative expression analysis by qPCR on intestinal biopsy samples from the jejunum of IBS-D patients compared to controls.

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