Sporadic Hirschsprung Disease: Mutational Spectrum and Novel Candidate Genes Revealed by Next-generation Sequencing.

Sci Rep · 2017 · PMC5666020 · PMID 29093530

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nominally significantP = 3.35E-05actually significant

Among the 13 genes in which LGD strict variants were detected, only RET displayed nominally significant enrichment for rare damaging variants and passed the burden test ( P = 3.35E-05, FDR = 0.00047, other data not shown).

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