Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment.

MHC I showed a trend increase in expression on niDCs compared to iDCs, and there was no change in CD80 expression after treatment with neuraminidase. ntDCs (Figure 3 B, ii) displayed a significant increase in both MHC I and MHC II with no changes in CD80 and a trend increase in CD86 after neuraminidase treatment. niDC and ntDC populations were also assessed for expression of pro- and anti-inflammatory markers by qRT-PCR (Figure 3 C).

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We noted highly significant changes in lectin binding for α2-6-linked Sia (SNA-I) with no significant changes in lectin binding for α2-3-linked Sia (MAL-II).

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