A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer.

Br J Cancer · 2017 · PMC5672937 · PMID 28881357

Europe PMC DOI

hedged sentences

0.2242

closest p · 4.5× alpha

0.2242

boldest claim

The sentences

a clear trendP =0.2242not close (p > 0.1)

failed to reach significanceno p-value reported

Kaplan–Meier survival analysis of AnxA6 with outcome in PDAC Kaplan–Meier survival analysis carried out using GraphPad PRISM revealed a clear trend towards high AnxA6 expression (IHC score 3+/4+) being associated with a poorer outcome in the 57 PDAC cohort ( P =0.2242); however, this failed to reach significance.

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highly significantno p-value reported

A highly significant correlation was shown between high AnxA6 IHC score (3+/4+) and the presence of perineural invasion (PNI) ( P = <0.0001).

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