Neuropathological and transcriptomic characteristics of the aged brain.

As expected, these region-specific inflammation gene networks (HIP_M18, TCx_M18, PCx_M18, FWM_M13) show highly significant gene overlap (hypergeometric test, p<10 −100 ), despite being generated independently.

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Measures of Aβ pathology show nominally significant, but less robust associations with disease and cognitive status ( Figure 2B–D , bottom row), aligning with previous reports that pTau may be a better indicator of AD severity than Aβ ( Nelson et al., 2007 ).

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