Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress.

Consistent with improved glycemia, WT mice showed a trend towards lower fasting plasma insulin after training (Sedentary vs. trained: 10.29 ± 1.91 vs. 5.86 ± 1.91; p = 0.052), whereas S6K1KO mice displayed lower insulin levels in both sedentary and trained states compared to WT ( Figure 3 B).

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