Interestingly, we found a significant negative correlation with plasma DPP4 activity and a positive association with PBMC DPP4 activity with fraction of CD26+IL17+ subset within CD4+ T cells (although the later did not reach statistical significance; r = 0.443, p = 0.098) ( Figure 5 C,D).
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KLK5 induces shedding of DPP4 from circulatory Th17 cells in type 2 diabetes.
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