In our study, we also confirmed these findings, but after haplotype reconstruction we also found that only the HLA-DRB1*07:01–HLA-DQB1*02:02 haplotype associated significantly, and the HLA-DRB1*07:01–HLA-DQB1*03:03 haplotype did not reach statistical significance, possibly because of the lower allele frequency (0.038 vs. 0.091 for the HLA-DRB1*07:01–HLA-DQB1*02:02 haplotype).
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HLA-DRB1*07:01-HLA-DQA1*02:01-HLA-DQB1*02:02 haplotype is associated with a high risk of asparaginase hypersensitivity in acute lymphoblastic leukemia.
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