We analyzed the PTC TCGA data set [ 1 ]; 5p showed a trend in increase of copy-number (0.2 cutoff) from stage I (0%) to stage III (3.5%) in BRAF V600E -PTC, and from 1.03% in stage I to 13.04% in stage III in BRAF WT -PTC.
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Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAF<sup>V600E</sup>.
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