Exercise and gastrointestinal symptoms: running-induced changes in intestinal permeability and markers of gastrointestinal function in asymptomatic and symptomatic runners.

In the symptomatic group, there was a trend for higher serum I-FABP concentrations after running but it did not reach statistical significance (baseline: 389 ± 327 pg/ml; after run: 961 ± 949 pg/ml).

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This is an interesting trend and taken together with previous reports that have described a correlation with increased pro-inflammatory cytokines and GI symptoms during exercise (Jeukendrup et al. 2000 ; Gill et al. 2015 ), highlights the possible role of inflammation in mediating some of the detrimental effects of exercise on the GI tract.

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