Can physical assessment techniques aid diagnosis in people with chronic fatigue syndrome/myalgic encephalomyelitis? A diagnostic accuracy study.

A McNemar’s test found no statistically significant bias in the diagnosis by the experienced AHP relative to actual diagnosis (p=1.0) and a marginally non-significant bias by the newly trained AHP (p=0.052).

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However, for the AHP with no prior Perrin technique experience, they were able to detect 86% of healthy controls but identified only 69% of patients with CFS/ME using all five signs; there was borderline non-significant evidence of this AHP underdiagnosing rather than overdiagnosing CFS/ME.

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