Enhancement of the anti-tumor activity of FGFR1 inhibition in squamous cell lung cancer by targeting downstream signaling involved in glucose metabolism.

Compared to controls, a significant 46.29% reduction in GLUT-1 positive cells was documented in tumors treated with the combination of NVP-BGJ398 and NVP-BEZ235 while the inhibitory effect of individual drugs did not reach statistical significance (Figure 9c, 9d ).

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