β2GPI exerts an anti-obesity effect in female mice by inhibiting lipogenesis and promoting lipolysis.

There was a trend showing an increase of leptin levels in female β2GPI-/- mice fed a HF diet compared to WT females fed a high fat diet, but it did not reach statistical significance (Figure 7 ).

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When female WT mice were fed a HF diet there was a highly significant down regulation of lipogenesis enzymes compared to female WT mice fed NC (Figure 4A, 4B ).

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