Characterization of the early molecular changes in the glomeruli of Cd151 ^-/- mice highlights induction of mindin and MMP-10.

Whilst none of the Mmp genes appeared in the p -value filtered list of differentially expressed genes (Supplementary Tables S2 and S3 , with p < 0.05), on examination of the unfiltered results Mmp-10 was the only one showing a large fold change (x10.2) that was approaching significance ( p = 0.08).

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The filtered data set was analysed using SAM, with 3000 permutations and 20% FDR to identify only the most highly significant gene expression changes.

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